Activated Protein C Resistance

Definition

Definition of Activated Protein C Resistance
Activated protein C resistance is a hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). This results in an increased risk of venous thrombosis, which can cause heart attacks, strokes, and other problems with circulation.

The disorder can be acquired or inherited, the hereditary form having an autosomal dominant inheritance pattern.

Symptoms

Symptoms of Activated Protein C Resistance
Activated protein C (with protein S as a cofactor) degrades Factor Va and Factor VIIIa. Activated protein C resistance is the inability of protein C to cleave Factor Va and/or Factor VIIIa, which allows for longer duration of thrombin generation and may lead to a hypercoagulable state. This may be hereditary or acquired.

Causes

Causes of Activated Protein C Resistance
Up to 64% of patients with venous thromboembolism might have activated protein C resistance.

Diagnosis

Diagnosis of Activated Protein C Resistance
Diagnostic and therapeutic approaches to the infant or child with VTE.

Prognosis

Prognosis of Activated Protein C Resistance
Consult with your doctor.

Treatment

Treatment of Activated Protein C Resistance
The approach to the adult patient with established VTE will be discussed here, with emphasis upon clinical features and the indications for testing for an inherited or acquired cause of thrombophilia.

Prevention

Prevention of Activated Protein C Resistance
Consult with your doctor.