Acute Myeloblastic Leukemia (Without Maturation)

Definition

Definition of Acute Myeloblastic Leukemia (Without Maturation)
Acute myeloblastic leukemia without maturation is a quickly progressing disease in which too many immature white blood cells (not lymphocytes) are found in the blood and bone marrow.

Symptoms

Symptoms of Acute Myeloblastic Leukemia (Without Maturation)
The list of signs and symptoms for Acute myeloblastic leukemia type 2 includes the 50 symptoms listed below:

1. Asthenia
2. Pallor
3. Fever
4. Dizziness
5. Respiratory symptoms
6. Easy bruising
7. Excessive bleeding
8. Coagulation disorders
9. Neurological disorders
10. Enlarged gums
11. Severe thrombocytopenia
12. Bleeding gums
13. Prolonged menstrual bleeding
14. Weakness
15. Fatigue
16. Palpitations
17. Bone pain
18. Abdominal pain
19. Headache
20. Chest pain
21. Shortness of breath
22. Urination pain
23. Enlarged liver
24. Enlarged spleen
25. Weight loss
26. Asthenia
27. Pallor
28. Fever
29. Dizziness
30. Respiratory symptoms
31. Easy bruising
32. Excessive bleeding
33. Coagulation disorders
34. Neurological disorders
35. Enlarged gums
36. Severe thrombocytopenia
37. Bleeding gums
38. Prolonged menstrual bleeding
39. Weakness
40. Fatigue
41. Palpitations
42. Bone pain
43. Abdominal pain
44. Headache
45. Chest pain
46. Shortness of breath
47. Urination pain
48. Enlarged liver
49. Enlarged spleen
50. Weight loss

Causes

Causes of Acute Myeloblastic Leukemia (Without Maturation)
This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21). On both sides of the splice the DNA coded for different proteins, RUNX1 and ETO, These two sequences are then transcribed and translated into a single large protein, "M2 AML" which allows the cell to divide unchecked, leading to cancer.

Diagnosis

Diagnosis of Acute Myeloblastic Leukemia (Without Maturation)
Home medical testing related to Acute myeloblastic leukemia with maturation:

1. Colon and Rectal Cancer: Home Testing
2. Home Colorectal Cancer Tests
3. Home Fecal Occult Bleeding Tests

Treatment

Treatment of Acute Myeloblastic Leukemia (Without Maturation)
Systemic chemotherapy includes alkylating agents - usually chlorambucil, cyclophosphamide, vincristine, or fludarabine (singly or in combination) - and steroids (prednisone) when autoimmune hemolytic anemia or thrombocytopenia occurs.

An advance in the treatment of CLL has been the emergence of the humanized monoclonal antibodies rituximab and alemtuzumab. Alemtuzumab acts as an antibody against the surface of CLL cells and is used when fludarabine fails. Rituximab, a monoclonal antibody, acts similiarly to alemtuzumab; studies are ongoing.

When chronic lymphocytic leukemia causes obstruction or organ impairment or enlargement, local radiation treatment can be used to reduce organ size. Allopurinol can be given to prevent hyperuricemia, a relatively uncommon finding.

Prognosis is poor if anemia, thrombocytopenia, neutropenia, bulky lymphadenopathy, and severe lymphocytosis are present.

Prognosis

Prognosis of Acute Myeloblastic Leukemia (Without Maturation)
Consult with your doctor.