Andersen's Disease

Definition

Definition of Andersen's Disease
Andersen’s disease, also called Glycogenosis Type Iv, extremely rare hereditary metabolic disorder produced by absence of the enzyme amylo-1:4,1:6-transglucosidase, which is an essential mediator of the synthesis of glycogen. An abnormal form of glycogen, amylopectin, is produced and accumulates in body tissues, particularly in the liver and heart. Affected children appear normal at birth but fail to thrive and later lose muscle tone, becoming lethargic.

Symptoms

Symptoms of Andersen's Disease
The list of signs and symptoms for Andersen disease listed below:

1. Failure to thrive
2. Poor infant weight gain
3. Lack of infant muscle tone
4. Gastrointestinal problems
5. Enlarged liver
6. Enlarged spleen
7. Liver cirrhosis
8. Edema
9. Abnormal fluid buildup in abdomen
10. Neurological abnormalities
11. Muscular atrophy
12. Reduced tendon reflexes

Causes

Causes of Andersen's Disease
A rare hereditary metabolic disorder caused by absence of an enzyme needed to produce glycogen. Instead, an abnormal form of glycogen, amylopectin, is made and builds up in the body tissues, mainly the liver and heart.

Diagnosis

Diagnosis of Andersen's Disease
These home medical tests may be relevant to Andersen disease:

* Liver Health & Hepatitis: Home Testing

• Home Hepatitis Tests
• Home Liver Tests
• Sexually Transmitted Disease Tests

Treatment

Treatment of Andersen's Disease
Consult with your doctor.

Prognosis

Prognosis of Andersen's Disease
Complications and sequelae of Andersen disease from the Diseases Database include:

1. Hepatic failure
2. Hydrops fetalis
3. Splenomegaly
4. Cirrhosis of liver

Prevention

Prevention of Andersen's Disease
Consult with your doctor.