Bowenoid Papulosis

Definition

Definition of Bowenoid Papulosis
Bowenoid Papulosis a form of high-risk genital warts, but more recently is now thought to be an early form of cancer caused by a variety of high-risk human papilloma viruses (HPV), usually HPV 16 and 18. It can also cause Malignancy. Women are at greater risk for cervical cancer if they or their partners have Bowenoid Papulosis. It is a sexually transmitted infection that may have severe results.

1. Human Papilloma Virus
2. Anogenital Cancer
3. Anal Intraepithelial Neoplasia
4. Verrucae
5. Condyloma

Symptoms

Symptoms of Bowenoid Papulosis
Some of the major signs and symptoms of the disease may include:

1. Red warty bump on genitals
2. Brown warty bump on genitals
3. Flesh-colored warty bump on genitals

Causes

Causes of Bowenoid Papulosis
Bowenoid papulosis tends to spontaneously disappear within several months and if a young woman is pregnant when it is diagnosed it will often disappear after delivery. If it is persistent this is an indication for active treatment because of the chance of developing skin cancer.

Diagnosis

Diagnosis of Bowenoid Papulosis
The complete diagnosis of the disease may include:

1. The disease may well identified by studying the symptoms.
2. Select a typical bowenoid papulosis lesion for cutaneous biopsy, and send it for routine histologic evaluation.
3. White vinegar (5% acetic acid) application may make subclinical bowenoid papulosis lesions visible within 5-10 minutes.

Pathophysiology

Pathophysiology of Bowenoid Papulosis
Bowenoid papulosis is a focal epidermal hyperplasia and dysplasia induced by HPV infection (most commonly by HPV 16). The result is a papule demonstrating scattered atypical cells or full-thickness epidermal atypia that some view as analogous to squamous cell carcinoma in situ. This epidermal atypia is sometimes known as bowenoid dysplasia.

Treatment

Treatment of Bowenoid Papulosis
Immunomodulators have been researched to be the effective treatment for the disease. The most effective treatment for Bowenoid Papulosis is simple local destruction of the lesions. There are various modalities that have been used, although recurrences are common with all. The modalities include simple local excision, electrodessication, cryosurgery, laser surgery, and use of topical retinoic acid, podophyllum resin, and topical 5-fluorouracil.

Some other activities that may help during the disease are:

1. Patients with perianal involvement should consider scheduling an examination with a proctologist..
2. Patients with urethral involvement should consider receiving an examination by a urologist.
3. Female patients and women who have had sexual relations with male patients should be seen for a thorough cervical examination because of the increased risk of malignancy.