Carney Syndrome

Definition

Definition of Carney Syndrome
Carney complex (CNC) is a familial multiple neoplasia and lentiginosis syndrome. Historically, the complex involved the association of the following conditions: (1) primary pigmented nodular adrenocortical disease (PPNAD), a pituitary-independent, primary adrenal form of hypercortisolism; (2) lentigines, ephelides, and blue nevi of the skin and mucosae; and (3) a variety of nonendocrine and endocrine tumors. The latter include myxomas of the skin, heart, breast, and other sites; psammomatous melanotic schwannoma; growth hormone–producing pituitary adenoma; testicular Sertoli-cell tumor; and, possibly, other benign and malignant neoplasms and conditions, including tumors of the thyroid gland and ductal adenoma of the breast and acromegaly due to somatomammotroph hyperplasia and adenoma not dependent on growth hormone–releasing hormone.

Symptoms

Symptoms of Carney Syndrome
The list of signs and symptoms for Carney syndrome listed below:

1. Spotted pigmentation on skin
2. Acromegaly
3. Blue skin spots
4. Benign tumors

Causes

Causes of Carney Syndrome
To research the causes of Carney syndrome, consider researching the causes of these these diseases that may be similar, or associated with Carney syndrome:

1. Gastric epithelioid leiomyosarcoma
2. Pulmonary chondroma
3. Extra-adrenal paraganglioma

Diagnosis

Diagnosis of Carney Syndrome
The phrase "signs of Carney syndrome" should, strictly speaking, refer only to those signs and symptoms of Carney syndrome that are not readily apparent to the patient. The word "symptoms of Carney syndrome" is the more general meaning; see symptoms of Carney syndrome.

Treatment

Treatment of Carney Syndrome
Cardiac myxomas can be difficult to manage surgically because of recurrence within the heart, often far away from the site of the initial tumor.

Prognosis

Prognosis of Carney Syndrome
Consult with your doctor.

Prevention

Prevention of Carney Syndrome
Consult with your doctor.